Hotels in Southern Illinois

Free cancellation options if plans change
Unlock travel rewards with One Key
Save more with Member Prices

Check prices for these dates

Tonight
May 7 - May 8
Tomorrow
May 8 - May 9
This weekend
May 9 - May 11
Next weekend
May 16 - May 18

Where to stay in Southern Illinois?

Laketree Inn And Suites Marion
Suite, Accessible, Non Smoking | Blackout drapes, soundproofing, iron/ironing board, free WiFi

Laketree Inn And Suites Marion

2.0 star property
7.8 out of 10, Good, (149)
The price is $83
includes taxes & fees
$74 per night
May 19 - May 20
Laketree Inn And Suites Marion
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southern Illinois, IL

Showing deals for:May 16 - May 18

Image gallery for The Principal Hotel

Exterior
VIP Access

The Principal Hotel

2.0 star property
Columbia
9.8/10Exceptional (51 reviews)
25% off
Price is $172
per night
$381 total
includes taxes & fees
The Principal Hotel

Top landmarks in Southern Illinois

Campus Lake at Southern Illinois University in Carbondale, IL.

Southern Illinois University

If you'd like to get a taste of Carbondale student life, check out Southern Illinois University, located 1.1 mi (1.7 km) from central Carbondale.

See properties in Southern Illinois University
Southern Illinois University

Learn more about Southern Illinois

Southern Illinois is applauded for its entertainment and live music with such cultural attractions as Effingham Performance Center and Popeye Museum. Visitors highlight this family-friendly city's sports while sights include Jefferson County Fairgrounds and Salem Fairgrounds.

See all hotels in Southern Illinois
Southern Illinois showing forest scenes, a sunset and landscape views
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
Sign in or join for free

Frequently asked questions

What accommodations do travelers recommend in Southern Illinois?
Mcgrady Inn, Davie School Inn and Best Western Plus Parkside Inn & Suites are all properties that our guests really like.
Can I book refundable hotels in Southern Illinois?
If you want the flexibility to change your travel plans to Southern Illinois, most accommodations offer refundable* bookable rates. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow down the results.
Which Southern Illinois hotels do guests like for their central location?
Our guests rave about the location of these properties: Comfort Suites Mount Vernon, Drury Inn & Suites Mt. Vernon and Drury Inn & Suites St. Louis Fairview Heights.
Where should I consider staying in Southern Illinois if I want a reasonably priced accommodation?
Comfort Suites Mount Vernon, Baymont by Wyndham Marion and Ramada by Wyndham Effingham are a few accommodations you might want to consider that’ll save you money. You can browse more choices on our site, including 65 motels.
Where can I stay in Southern Illinois if I want a vacation home instead of a traditional hotel?
If you’re looking for a good alternative to a hotel, review our selection of 261 vacation homes. In addition, there are 77 apartments and 6 condos.
Why should I book my Southern Illinois hotel through Hotels.com?
There are plenty of reasons to book your Southern Illinois travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

https://www.hotels.com/lp/b/deals