Hotels in Defiance

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Where to stay in Defiance?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Defiance on Hotels.com. These Defiance hotels consistently deliver on comfort, location and traveler experience. Last updated on August 13, 2026.

Premium bedding, desk, iron/ironing board, WiFi (free)

Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

$82 nightly

Sep 3 - Sep 4

Total with taxes and fees

Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

$101 nightly

Aug 23 - Aug 24

Total with taxes and fees

The Wildwood Hotel

Wildwood

$80 nightly

Aug 24 - Aug 25

Total with taxes and fees

Standard Room, 2 Queen Beds, Non Smoking | Hypo-allergenic bedding available, desk, laptop workspace

Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

$88 nightly

Aug 23 - Aug 24

Total with taxes and fees

TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

$128 nightly

Aug 28 - Aug 29

Total with taxes and fees

Courtyard by Marriott St. Louis Chesterfield

Chesterfield

$105 nightly

Aug 28 - Aug 29

Total with taxes and fees

Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

$114 nightly

Sep 7 - Sep 8

Total with taxes and fees

Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

$110 nightly

Aug 30 - Aug 31

Total with taxes and fees

Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

$139 nightly

Aug 20 - Aug 21

Total with taxes and fees

Residence Inn by Marriott O'Fallon

O'Fallon

$131 nightly

Aug 28 - Aug 29

Total with taxes and fees

Holiday Inn St. Louis West Six Flags by IHG

Eureka

$105 nightly

Sep 7 - Sep 8

Total with taxes and fees

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

$111 nightly

Sep 13 - Sep 14

Total with taxes and fees

Quality Inn Near Six Flags St. Louis

Pacific

$94 nightly

Aug 16 - Aug 17

Total with taxes and fees

Comfort Inn Near Six Flags St. Louis

Pacific

$95 nightly

Sep 13 - Sep 14

Total with taxes and fees

Best Western Plus Washington Hotel

Washington

$129 nightly

Aug 16 - Aug 17

Total with taxes and fees

Super 8 by Wyndham Eureka/Six Flags Nearby

Eureka

$66 nightly

Sep 13 - Sep 14

Total with taxes and fees

Fairfield Inn & Suites Wentzville

Wentzville

$128 nightly

Aug 23 - Aug 24

Total with taxes and fees

Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

$118 nightly

Sep 13 - Sep 14

Total with taxes and fees

Hampton Inn St. Louis Wentzville

Wentzville

$147 nightly

Aug 23 - Aug 24

Total with taxes and fees

Drury Inn & Suites St. Louis St. Peters

St. Peters

$106 nightly

Sep 13 - Sep 14

Total with taxes and fees

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Go beyond your typical stay in Defiance

Pet friendly

Apartment

Top landmarks in Defiance

A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

If you like spending time outside, why not spend the afternoon at August A. Busch Memorial Conservation Area, a park located 30.2 mi (48.6 km) from the center of St. Louis.

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Learn more about Defiance

Defiance is well-known for its attractions such as Chandler Hill Vineyards and Sugar Creek Winery.

See all hotels in Defiance

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Check out reviews of Defiance hotels guests love

Best Western Plus St. Louis West-Westport

10/10 Excellent

"Good location, although there needs to be clear signage to locate the property. I never saw a sign for the hotel and GPS wasn’t very helpful. Otherwise, my stay was very good. I appreciated the available laundry facilities."

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

10/10 Excellent

"There was plenty of parking, AC worked like a dream, the beds were super comfy, and the staff was so kind, patient, and helpful. The only thing we were sad about was the pool. It wasn't dirty, it just looked a little too green and we don't know why. We didn't ask or press the issue because honestly we were out of the hotel for most of the time we were there. It may have been perfectly fine. We saw someone else getting ready to get into it. We were going to be checking in really late and they accommodated us. We got down to breakfast late one day, and they patiently waited for us to finish. We stayed for two nights. We had one bedroom with two queen size beds and it did not feel like the four of us were on top of each other, there was so much space! Overall good experience!!"

Hampton Inn St. Charles St. Peters

10/10 Excellent

"The hotel is in excellent condition. It’s either new or newly remodeled. Bed was super comfortable and pillows awesome. The breakfast area offered a lot to choose from. I highly recommend this hotel at this location in St Charles MO and would definitely stay again. Hotel exit is right off the highway which was very convenient. We stayed in room 416 and it was very quiet!"

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

8/10 Good

"Missing shower curtain in one of the bathrooms , call the front desk multiple times was never able to get a hold of anybody, check out was 11. Our keys stopped working at nine difficult to load our cars when we kept getting locked out. .. hotel was very clean pool area very nice and clean front desk very helpful and nice."

Frequently asked questions

How much does a hotel room cost in Defiance?

You can discover great hotels in Defiance from $77 with properties to suit all budgets and needs. If you're looking for an affordable hotel in Defiance that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at Defiance hotels?

Discover great deals on Defiance hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on Defiance hotels.

Can I book Defiance hotels with free cancellation?

It's easy to book a refundable Defiance hotel on Hotels.com. Simply filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What are some popular hotels in central Defiance?

If you're looking for hotels in central Defiance, check out The Inns at St. Albans near Six Flags. Travelers love The Inns at St. Albans near Six Flags for its location, as well as the garden-view restaurant, golf clubhouse and free parking this inn offers.

What hotels do travelers recommend in Defiance?

Guests like The Wildwood Hotel and Sleep Inn & Suites O'Fallon MO - Technology Drive.

Can I book refundable accommodations in Defiance?

If you need the flexibility to change your plans to Defiance, most hotels offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Defiance be like during my vacation?

July and August are typically the warmest months in Defiance when the average temp is 76°F. January and February are the coldest months when the average temperature is 38°F. May and April are the months with the most rain.

Why should I book my Defiance hotel through Hotels.com?

There are lots of reasons to book your Defiance trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.