If you're looking to discover somewhere new, look no further than Mytilene. Whether you're planning to stay for a night or for the week, the area around Mytilene has accommodation options to fit every need. Search for hotels in Mytilene with Hotels.com by checking our online map. Our map displays the areas and neighbourhoods around all Mytilene hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Mytilene hotel deals are here with our lowest price guarantee.
Hotels in Mytilene
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ISSA Lesvos
ISSA Lesvos
9.6 out of 10, Exceptional, (12)

Theofilos Paradise Boutique Hotel
Theofilos Paradise Boutique Hotel
9.6 out of 10, Exceptional, (146)

Mythical Coast Wellness Retreat
Mythical Coast Wellness Retreat
8.8 out of 10, Excellent, (31)

The Loriet
The Loriet
8.4 out of 10, Very good, (64)

Ampoulos Rooms & Apartments
Ampoulos Rooms & Apartments
8.2 out of 10, Very good, (19)

Heliotrope Hotels
Heliotrope Hotels
8.6 out of 10, Excellent, (183)

Hotel Lesvion
Hotel Lesvion
9.6 out of 10, Exceptional, (89)

Studio 5
Studio 5

Elies Residences
Elies Residences
10.0 out of 10, Exceptional, (29)

Agora Apartments
Agora Apartments
10.0 out of 10, Exceptional, (1)

Heliotrope The Studios
Heliotrope The Studios
8.8 out of 10, Excellent, (44)

Nitelli's Houses
Nitelli's Houses
9.0 out of 10, Wonderful, (14)

Olive Green Studios and Apartments
Olive Green Studios and Apartments
10.0 out of 10, Exceptional, (1)

Vicky Studios
Vicky Studios
10.0 out of 10, Exceptional, (2)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Mytilene
Top landmarks in Mytilene
Port of Mytilene
Explore the waterfront in Mytilene with a trip to Port of Mytilene. While you're in the area, stroll along the seaside.
Learn more about Mytilene
Notable for its seaside, Mytilene features attractions such as Port of Mytilene and Mytilini Castle.

Check out reviews of Mytilene hotels guests love

Theofilos Paradise Boutique Hotel
10/10 Excellent
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