Hotels in Southwest Illinois

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May 3 - May 4
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May 9 - May 11
In two weeks
May 16 - May 18

Where to stay in Southwest Illinois?

Drury Plaza Hotel Mt. Vernon
Lobby

Drury Plaza Hotel Mt. Vernon

3.0 star property
9.6 out of 10, Exceptional, (1305)
The price is $130
includes taxes & fees
$115 per night
May 4 - May 5
Drury Plaza Hotel Mt. Vernon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southwest Illinois, IL

Showing deals for:May 16 - May 18

Image gallery for Makanda Inn

Front of property - evening/night

Makanda Inn

3.5 star property
Makanda
10/10Exceptional (31 reviews)
9% off
Price is $293
per night
$669 total
includes taxes & fees
Makanda Inn

Top landmarks in Southwest Illinois

Campus Lake at Southern Illinois University in Carbondale, IL.

Southern Illinois University

If you'd like to get a taste of Carbondale student life, check out Southern Illinois University, located 1.1 mi (1.7 km) from central Carbondale.

See properties in Southern Illinois University
Southern Illinois University

Learn more about Southwest Illinois

Southwest Illinois is applauded for its entertainment and live music with such cultural attractions as Popeye Museum and Henry N Barkhausen Cache River Wetlands Center. The city has something for everyone including its sports, restaurants, and sights like DuQuoin State Fairgrounds and Rend Lake.

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Southern Illinois which includes a lake or waterhole and forests
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What accommodations do travelers like in Southwest Illinois?
Davie School Inn, Hart Estate Bed and Breakfast and Best Western Plus Centralia Hotel & Suites are all accommodations that are popular with guests.
Can I book refundable accommodations in Southwest Illinois?
If you’re looking for the flexibility to change your travel plans to Southwest Illinois, most properties provide refundable* rates you can book. You can see these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
Which Southwest Illinois hotels do travelers like for their great location?
Travelers like these properties for their convenient location: Comfort Suites Mount Vernon, Super 8 by Wyndham O’Fallon and Quality Inn & Suites near St. Louis and I-255. For quiet surroundings, guests like Baymont by Wyndham O’Fallon St. Louis Area.
Where should I consider staying in Southwest Illinois if I'm looking for a reasonably priced accommodation?
A few inexpensive options worth considering are Comfort Suites Mount Vernon, Super 8 by Wyndham O’Fallon and Quality Inn & Suites near St. Louis and I-255. You may want to browse more choices on our site, including 43 motels.
Where can I stay in Southwest Illinois if I want a vacation home instead of a hotel?
If you want to find a good alternative to a hotel, browse our selection of 193 vacation homes. In addition, there are 70 apartments and 5 condos.
Why should I book my Southwest Illinois hotel through Hotels.com?
There are plenty of reasons to book your Southwest Illinois travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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