Photo by Bryce Gordon
Hotels in Cambridge
Free cancellation options if plans change
Unlock travel rewards with One Key
Save more with Member Prices
Check prices for these dates
Where to stay in Cambridge?
Holiday Inn Express Des Moines Ankeny by IHG
Holiday Inn Express Des Moines Ankeny by IHG
2.5 star property
Ankeny
9.4 out of 10, Exceptional, (293)
9.4/10
Exceptional
(293)
$85 nightly
The price is $95
$95 total
Dec 12 - Dec 13
Total with taxes and fees
Comfort Inn and Suites Ames near ISU Campus
Comfort Inn and Suites Ames near ISU Campus
2.5 star property
Ames
9.0 out of 10, Wonderful, (981)
9.0/10
Wonderful
(981)
$80 nightly
The price is $89
$89 total
Dec 26 - Dec 27
Total with taxes and fees
Comfort Inn Story City
Comfort Inn Story City
2.5 star property
Story City
8.8 out of 10, Excellent, (383)
8.8/10
Excellent
(383)
$80 nightly
The price is $90
$90 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
Courtyard by Marriott Ames
Courtyard by Marriott Ames
3.0 star property
Ames
9.2 out of 10, Wonderful, (281)
9.2/10
Wonderful
(281)
$87 nightly
The price is $97
$97 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
GrandStay Hotel & Suites
GrandStay Hotel & Suites
2.0 star property
Johnston
9.4 out of 10, Exceptional, (478)
9.4/10
Exceptional
(478)
$85 nightly
The price is $95
$95 total
Dec 7 - Dec 8
Total with taxes and fees
Home2 Suites By Hilton Ames
Home2 Suites By Hilton Ames
3.0 star property
Ames
9.4 out of 10, Exceptional, (14)
9.4/10
Exceptional
(14)
$86 nightly
The price is $96
$96 total
Dec 21 - Dec 22
Total with taxes and fees
Tru By Hilton Grimes Des Moines
Tru By Hilton Grimes Des Moines
2.5 star property
Grimes
9.2 out of 10, Wonderful, (20)
9.2/10
Wonderful
(20)
$79 nightly
The price is $89
$89 total
Dec 21 - Dec 22
Total with taxes and fees
Microtel Inn & Suites by Wyndham Colfax/Newton
Microtel Inn & Suites by Wyndham Colfax/Newton
2.0 star property
Colfax
7.6 out of 10, Good, (584)
7.6/10
Good
(584)
$55 nightly
The price is $62
$62 total
Dec 9 - Dec 10
Total with taxes and fees
Gateway Hotel and Conference Center at Iowa State University
Gateway Hotel and Conference Center at Iowa State University
3.0 star property
Ames
9.2 out of 10, Wonderful, (1184)
9.2/10
Wonderful
(1184)
$77 nightly
The price is $87
$87 total
Dec 18 - Dec 19
Total with taxes and fees
Best Western Plus University Park Inn & Suites
Best Western Plus University Park Inn & Suites
2.5 star property
Ames
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
$78 nightly
The price is $87
$87 total
Dec 8 - Dec 9
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA
La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA
3.0 star property
Ankeny
9.2 out of 10, Wonderful, (1001)
9.2/10
Wonderful
(1001)
$78 nightly
The price is $88
$88 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Hampton Inn & Suites Altoona-Des Moines
Hampton Inn & Suites Altoona-Des Moines
2.5 star property
Altoona
9.2 out of 10, Wonderful, (669)
9.2/10
Wonderful
(669)
$90 nightly
The price is $101
$101 total
Dec 19 - Dec 20
Total with taxes and fees
Cobblestone Inn & Suites - Boone
Cobblestone Inn & Suites - Boone
2.5 star property
Boone
9.0 out of 10, Wonderful, (391)
9.0/10
Wonderful
(391)
$95 nightly
The price is $107
$107 total
Dec 28 - Dec 29
Total with taxes and fees
Holiday Inn Express & Suites Ames by IHG
Holiday Inn Express & Suites Ames by IHG
2.5 star property
Ames
8.6 out of 10, Excellent, (411)
8.6/10
Excellent
(411)
$85 nightly
The price is $95
$95 total
Dec 14 - Dec 15
Total with taxes and fees
Spark by Hilton Ames
Spark by Hilton Ames
3.0 star property
Ames
9.2 out of 10, Wonderful, (17)
9.2/10
Wonderful
(17)
$71 nightly
The price is $80
$80 total
Dec 14 - Dec 15
Total with taxes and fees
Home2 Suites By Hilton Altoona Des Moines
Home2 Suites By Hilton Altoona Des Moines
3.0 star property
Altoona
9.4 out of 10, Exceptional, (47)
9.4/10
Exceptional
(47)
$94 nightly
The price is $106
$106 total
Dec 19 - Dec 20
Total with taxes and fees
Stoney Creek Hotel Des Moines - Johnston
Stoney Creek Hotel Des Moines - Johnston
2.5 star property
Johnston
9.0 out of 10, Wonderful, (1789)
9.0/10
Wonderful
(1789)
$83 nightly
The price is $93
$93 total
Dec 9 - Dec 10
Total with taxes and fees
GrandStay Hotel & Suites
GrandStay Hotel & Suites
2.5 star property
Ames
8.4 out of 10, Very Good, (1000)
8.4/10
Very Good
(1000)
$81 nightly
The price is $91
$91 total
Dec 7 - Dec 8
Total with taxes and fees
Sleep Inn & Suites Ames near ISU Campus
Sleep Inn & Suites Ames near ISU Campus
2.5 star property
Ames
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
$63 nightly
The price is $71
$71 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Super 8 by Wyndham Ankeny/Des Moines Area
Super 8 by Wyndham Ankeny/Des Moines Area
2.0 star property
Ankeny
7.0 out of 10, Good, (633)
7.0/10
Good
(633)
$63 nightly
The price is $71
$71 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Cambridge
Pet friendly
Family friendly
Cottage
Learn more about Cambridge
Cambridge is well-known for its attractions such as Center Grove Orchard and Heart of Iowa Nature Trail.
Photo by Bryce Gordon
Open Photo by Bryce Gordon
Check out reviews of Cambridge hotels guests love
Hotel Fort Des Moines, Curio Collection by Hilton
10/10 Excellent
"Favorite hotel in DM. Great location, great staff."
Des Lux Hotel
10/10 Excellent
"Clean rooms and great breakfast options."
Comfort Inn & Suites Event Center
10/10 Excellent
"We couldn't make it due to a family emergency and a winter snowstorm, and the hotel was very understanding and very easy to work with. If I need a hotel in the area in the future this hotel will be my 1st choice. "
Stoney Creek Hotel Des Moines - Johnston
10/10 Excellent
"Impeccable"
Days Inn by Wyndham West Des Moines / Clive
10/10 Excellent
"Everything "
Home2 Suites by Hilton Des Moines at Drake University
10/10 Excellent
"Great beds. Spacious rooms. Good breakfast!"
Quality Inn & Suites Des Moines - Merle Hay Road
10/10 Excellent
"We stayed one night while traveling through Des Moines. The staff was friendly and very responsive to our questions. The room and bed were very comfortable. The pool looks great, although we didn’t use it. We did use the small fitness center. It has one treadmill, a stationary bike, and some free weights. Great value for price. We will stay here again on our return trip. "
Sonesta Essential Des Moines
10/10 Excellent
"Only thing I'd say needed to be done is I've noticed not every room has an ice bucket & don't understand the 3 pillow thing either. "
Hyatt Place Des Moines/Downtown
10/10 Excellent
"The room was very clean amd we had more an amazing stay"
Frequently asked questions
What accommodations do travelers recommend in Cambridge?
Can I book a refundable accommodation in Cambridge?
If you're looking for the flexibility to change your plans to Cambridge, most accommodations offer refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Cambridge be like during my trip?
July and August are typically the warmest months in Cambridge when the average temp is 71°F. January and February are the coldest months when the average temperature is 27°F. May and June are the months with the most rain.
Why should I book my Cambridge hotel with Hotels.com?
There are lots of reasons to book your Cambridge trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.