Photo by Cindy Keese

Hotels in Seneca

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Check prices for these dates

Tonight
May 3 - May 4
Tomorrow
May 4 - May 5
Next weekend
May 9 - May 11
In two weeks
May 16 - May 18

Where to stay in Seneca?

Quality Inn Seneca US-123
Room, 2 Double Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, blackout drapes

Quality Inn Seneca US-123

2.5 star property
8.0 out of 10, Very Good, (585)
The price is $101
includes taxes & fees
$93 per night
May 19 - May 20
Quality Inn Seneca US-123
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
trending_down

Our prices for hotels in Seneca are cheapest in January

See average prices and weather for all months

Price trends for hotels in Seneca

Pricing is based on two traveler single night rates
May
$156
Average price during May is $156
Jun
$124
Average price during June is $124
Jul
$148
Average price during July is $148
Aug
$167
Average price during August is $167
Sep
$146
Average price during September is $146
Oct
$147
Average price during October is $147
Nov
$129
Average price during November is $129
Dec
$126
Average price during December is $126
Jan
$122
Average price during January is $122
Feb
$125
Average price during February is $125
Mar
$127
Average price during March is $127
Apr
$142
Average price during April is $142
Currently viewing crowd sizes and weather for May.

May

trending_flatModerate crowds
High 79°F / low 59°F. Sunny most days.
79°
weather_sun
May, Moderate crowds, average high temperature 79 degrees Fahrenheit, average low temperature 59 degrees Fahrenheit. Sunny most days.
59°
87°
weather_sun
June, Moderate crowds, average high temperature 87 degrees Fahrenheit, average low temperature 66 degrees Fahrenheit. Sunny most days.
66°
90°
weather_sun
July, High crowds, average high temperature 90 degrees Fahrenheit, average low temperature 70 degrees Fahrenheit. Sunny most days.
70°
88°
weather_sun
August, High crowds, average high temperature 88 degrees Fahrenheit, average low temperature 69 degrees Fahrenheit. Sunny most days.
69°
83°
weather_sun
September, High crowds, average high temperature 83 degrees Fahrenheit, average low temperature 64 degrees Fahrenheit. Sunny most days.
64°
73°
weather_sun
October, High crowds, average high temperature 73 degrees Fahrenheit, average low temperature 53 degrees Fahrenheit. Sunny most days.
53°
62°
weather_sun
November, Low crowds, average high temperature 62 degrees Fahrenheit, average low temperature 43 degrees Fahrenheit. Sunny most days.
43°
54°
weather_sun
December, Low crowds, average high temperature 54 degrees Fahrenheit, average low temperature 39 degrees Fahrenheit. Sunny most days.
39°
51°
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January, Low crowds, average high temperature 51 degrees Fahrenheit, average low temperature 34 degrees Fahrenheit. Partly sunny.
34°
55°
weather_partly_sunny
February, Low crowds, average high temperature 55 degrees Fahrenheit, average low temperature 38 degrees Fahrenheit. Partly sunny.
38°
62°
weather_sun
March, Moderate crowds, average high temperature 62 degrees Fahrenheit, average low temperature 43 degrees Fahrenheit. Sunny most days.
43°
71°
weather_sun
April, Moderate crowds, average high temperature 71 degrees Fahrenheit, average low temperature 50 degrees Fahrenheit. Sunny most days.
50°
Monthly weather averages (˚F)
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Top neighborhoods in Seneca

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Serenity Bay

Saxony Forest's Serenity Bay neighborhood offers attractions including Lake Keowee.

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Serenity Bay

Learn more about Seneca

Seneca, well-known for its sports and university life, features attractions such as Keowee Reservoir and Lake Keowee. This family-friendly city has something for everyone including its waterfront, coffeehouses, and sights like Keowee Key Golf Course and Lake Hartwell.

See all hotels in Seneca
View from the dike in Clemson, SC. This trail is used by runners, bikers, and lots of dog walkers.
Photo by Cindy Keese
Open Photo by Cindy Keese
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What accommodations do travelers like in Seneca?
Tru by Hilton Seneca Clemson, Lakeside Lodge Clemson and Hampton Inn & Suites Seneca-Clemson Area are all properties that our guests really like.
Where can I find free parking at my hotel in Seneca?
Park your car for free at these properties: Quality Inn Seneca US-123, Hampton Inn & Suites Seneca-Clemson Area, SC and Best Western Seneca-Clemson. There are 5 choices you may want to check out on our site.
Can I book refundable accommodations in Seneca?
If you want the flexibility to change your travel plans to Seneca, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay with my pet in Seneca?
Your animal companion is welcome at these pet-friendly hotels: Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson, and Days Inn by Wyndham Seneca / Clemson Area. There are 7 options you can choose from on our site.
Which Seneca hotels do our guests like for their central location?
Our guests rave about the location of these properties: Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson and Quality Inn Seneca US-123.
Where can I stay in Seneca if I want a budget-friendly accommodation?
Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson and Quality Inn Seneca US-123 are a few accommodations you might want to consider that’ll save you money.
Where can I stay in Seneca if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 204 vacation homes. In addition, there are 8 apartments and 7 condos.
Where can I stay if I'm traveling to Seneca with my children?
Parents traveling with children may want to consider Fairfield Inn & Suites Seneca Clemson Univ Area and Beautiful Waterfront Retreat on Lake Keowee W/ Clemson game day parking pass .
Where should I stay in Seneca for a trip with my partner?
Beautiful Waterfront Retreat on Lake Keowee W/ Clemson game day parking pass is a great option for a romantic getaway.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 46°F. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

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