Hotels in Upstate South Carolina

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May 20 - May 21
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May 21 - May 22
This weekend
May 23 - May 25
Next weekend
May 30 - Jun 1

Where to stay in Upstate South Carolina?

Sleep Inn
Lobby

Sleep Inn

2.5 star property
5.8 out of 10, (479)
$68 nightly
The price is $75
May 29 - May 30
Total includes taxes and fees
Sleep Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Upstate South Carolina, SC

Showing deals for:May 30 - Jun 1

Image gallery for Cambria Hotel Greenville

Lobby

Cambria Hotel Greenville

3.0 star property
Greenville
9.4/10Exceptional (1,037 reviews)
15% off
Price is $288
$131 nightly
$288 total
Total includes taxes and fees
Cambria Hotel Greenville

Top neighborhoods in Upstate South Carolina

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Green Avenue

The Green Avenue neighborhood offers attractions such as Falls Park on the Reedy and Greenville Zoo.

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Green Avenue

Top landmarks in Upstate South Carolina

Clemson University

Clemson University

If you'd like to get a taste of Clemson student life, check out Clemson University, located 0.5 mi (0.9 km) from central Clemson.

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Clemson University

Learn more about Upstate South Carolina

Upstate South Carolina is applauded for its cultural attractions such as Heritage Park and Roper Mountain Science Center.

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Greenville - Spartanburg showing a sunset, tranquil scenes and mountains
Photo by South Carolina Department of Parks, Recreation & Tourism
Open Photo by South Carolina Department of Parks, Recreation & Tourism
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What hotels do travelers recommend in Upstate South Carolina?
Pettigru Place Bed & Breakfast, The Inn at Patrick Square and Residence Inn by Marriott Anderson Clemson are all properties that our guests really like.
Can I book a refundable hotel in Upstate South Carolina?
If you’re looking for the flexibility to change your travel plans to Upstate South Carolina, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Which Upstate South Carolina hotels do our guests like for their terrific location?
Our guests love these properties for their convenient location: Best Western Plus Greenville I-385 Inn & Suites, La Quinta Inn & Suites by Wyndham Greenville Haywood and Spartanburg Marriott.
Where should I stay in Upstate South Carolina if I want a cheap accommodation?
A few inexpensive options worth considering are Best Western Plus Greenville I-385 Inn & Suites, La Quinta Inn & Suites by Wyndham Greenville Haywood and Comfort Inn Greenville - Haywood Mall. You can browse more choices on our site, including 30 motels.
Where can I stay in Upstate South Carolina if I want a vacation rental instead of a traditional hotel?
If you’re looking for a good alternative to a hotel, review our selection of 1073 vacation homes. In addition, there are 111 apartments and 92 condos.
Why should I book my Upstate South Carolina hotel through Hotels.com?
There are lots of reasons to book your Upstate South Carolina trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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