Hotels in Santee

Free cancellation options if plans change
Unlock travel rewards with One Key
Save more with Member Prices

Check prices for these dates

Tonight
May 23 - May 24
Tomorrow
May 24 - May 25
This weekend
May 23 - May 25
Next weekend
May 30 - Jun 1

Where to stay in Santee?

Lewis and Clark Resort
32-inch LCD TV with digital channels, TV

Lewis and Clark Resort

2.5 star property
8.8 out of 10, Excellent, (210)
$127 nightly
The price is $134
May 26 - May 27
Total includes taxes and fees
Lewis and Clark Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Santee

Niobrara showing a river or creek and boating as well as a small group of people

Niobrara State Park

You can take time to visit Niobrara State Park during your travels to Niobrara. While you're in the area, wander around the parks.

See properties in Niobrara State Park
Niobrara State Park

Learn more about Santee

The region around Santee is home to attractions such as Lewis and Clark Lake and Niobrara State Park.

See all hotels in Santee
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
Sign in or join for free

Frequently asked questions

What hotels do travelers like in Santee?
Guests like Overlooks Lewis & Clark Lake/Missouri River Basin-3 Hours Northwest of Omaha.
Can I book refundable hotels in Santee?
If you want the flexibility to change your plans to Santee, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in Santee be like during my visit?
The warmest months in Santee are usually July and August with an average temp of 72°F. January and February are the chilliest months when the average temp is 26°F. The rainiest months are June and May.
Why should I book my Santee accommodation with Hotels.com?
There are lots of reasons to book your Santee trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

https://www.hotels.com/lp/b/deals