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Resorts & Hotels with Spas in Southeast Missouri

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This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

Resorts & Hotels with Spas in Southeast Missouri

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Southeast Missouri on Hotels.com. These Southeast Missouri Resorts & Hotels with Spas consistently deliver on quality, location and traveler experience. Last updated on .

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
  • Full-service spa
  • Indoor pool
  • Breakfast included
9.4 out of 10, Exceptional, (1,000 reviews)
Rejuvenation flows through every aspect of this tranquil wellness refuge. Guests rave about the amazing in-room jacuzzi tubs, while the full-service spa offers pampering treatments after invigorating workouts in the fitness center. Friendly staff ensure a stress-free stay.
$101 nightly
The price is $115
Oct 11 - Oct 12
Total with taxes and fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover your perfect spa hotel in Southeast Missouri

Pool
Breakfast included

Top landmarks in Southeast Missouri

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
Elephant Rocks State Park is 5.3 mi (8.5 km) from central Ironton, why not stop by during your stay.
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