Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Mississippi County on Hotels.com. These Mississippi County hotels consistently deliver on quality, location and traveler experience. Last updated on .
Mississippi County Hotels
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Where to stay in Mississippi County
Top hotels in Charleston
Super 8 by Wyndham Charleston/Sikeston East MO
Top hotels in East Prairie
Candlewood Suites Cape Girardeau by IHG
8/10 Very Good! (1,002 reviews)
Top hotels in Bertrand
Drury Plaza Hotel Cape Girardeau Conference Center
Top hotels in Wyatt
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
8.2/10 Very Good! (1,000 reviews)
Top cities in Mississippi County
Charleston
Charleston is known for its restaurants, and offers lots of things to see including Mississippi River and Ohio River.
East Prairie
East Prairie has lots of attractions such as Big Oak Tree State Park and Mississippi River.
Top landmarks in Mississippi County
Check out the Mississippi County hotels guests love right now
Holiday Inn Express & Suites Union City by IHG
10/10 Excellent
Find out more about Mississippi County
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