Hotels in Southeast Missouri

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Deerfield Inn & Suites Steele Near Blytheville I 55

Deerfield Inn & Suites Steele Near Blytheville I 55
2.5 star property
Steele
$50 nightly
The price is $55
Jun 12 - Jun 13
Total with taxes and fees
Deerfield Inn & Suites Steele Near Blytheville I 55

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,016 reviews)
This peaceful Jackson hotel features a relaxing hot tub and indoor swimming pool. Free breakfast, WiFi, and parking add value, while the helpful staff ensures a comfortable stay. Litz Park and Lazy L Safari Park are nearby attractions to explore.
$80 nightly
The price is $85
Jun 21 - Jun 22
Total with taxes and fees
Drury Inn & Suites Jackson MO

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
9.8 out of 10, Exceptional, (75 reviews)
Escape to these charming cabins where each unit offers a private patio and fully-equipped kitchenette for self-catering convenience. Part of Marriott Bonvoy's Outdoor Collection, this retreat provides free parking and climate control for year-round comfort.
$149 nightly
The price is $160
Jun 11 - Jun 12
Total with taxes and fees
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (196 reviews)
Discover Cape Girardeau from this hotel with free WiFi, parking, and continental breakfast. Take a refreshing dip in the indoor pool after exploring nearby attractions like Fort D Historic Site and Cape Splash Family Aquatic Center.
$93 nightly
The price is $105
Jun 18 - Jun 19
Total with taxes and fees
Fairfield Inn & Suites by Marriott Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,007 reviews)
Located minutes from Shawnee National Forest, this hotel offers a refreshing indoor pool and hot tub for unwinding after adventures. Enjoy complimentary breakfast, WiFi, and parking while being close to Cape Splash Family Aquatic Center.
$100 nightly
The price is $113
Jun 21 - Jun 22
Total with taxes and fees
Drury Plaza Hotel Cape Girardeau Conference Center

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (133 reviews)
This Cape Girardeau hotel offers convenient access to Shawnee National Forest and local nature attractions. Start each morning with free breakfast before exploring nearby conservation areas, then return for a swim in the indoor pool or a workout at the fitness center.
$89 nightly
The price is $102
Jul 1 - Jul 2
Total with taxes and fees
Tru By Hilton Cape Girardeau

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (97 reviews)
Adventure seekers can explore nearby hiking trails, kayaking, and rafting, then return to this welcoming hotel. Enjoy free continental breakfast, WiFi, and parking, plus exceptional service from the staff that guests consistently praise.
$95 nightly
The price is $103
Jun 11 - Jun 12
Total with taxes and fees
EC Reed's Mercantile and Hotel

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (1,008 reviews)
Minutes from North Main Street Historic District, this peaceful hotel offers 2 swimming pools and fitness options. Guests rave about the quiet atmosphere, complimentary breakfast, and exceptionally helpful staff. Free WiFi and parking enhance your comfortable Missouri stay.
$94 nightly
The price is $106
Jun 28 - Jun 29
Total with taxes and fees
Drury Inn & Suites Poplar Bluff

Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
9.0 out of 10, Wonderful, (629 reviews)
Tee off at the 18-hole course, then unwind in the indoor pool and hot tub at this welcoming Farmington escape. Near Crown Pointe Golf Club, this hotel offers free breakfast, WiFi, parking, and a fitness center with terrace views.
$102 nightly
The price is $111
Jun 28 - Jun 29
Total with taxes and fees
Crown Pointe Lodge, BW Signature Collection

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (868 reviews)
Wake up to a tasty free breakfast at this Poplar Bluff hotel with indoor pool and fitness center. Just minutes from local attractions like Margaret Harwell Art Museum, you'll appreciate the free WiFi, complimentary parking, and attentive staff that guests consistently praise.
$93 nightly
The price is $105
Jul 5 - Jul 6
Total with taxes and fees
Hampton Inn Poplar Bluff

Fort Davidson Hotel

Fort Davidson Hotel
2.5 star property
Ironton
9.2 out of 10, Wonderful, (179 reviews)
Escape to this welcoming hotel featuring an outdoor pool, free parking, and convenient train station pickup. Explore nearby Fort Davidson State Historic Site and Battle of Pilot Knob Museum, all while enjoying complimentary WiFi throughout your stay.
$125 nightly
The price is $137
Jun 14 - Jun 15
Total with taxes and fees
Fort Davidson Hotel

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,008 reviews)
Escape to this serene Sikeston hotel with both indoor and outdoor pools near restaurants and shopping. The fitness center, free breakfast, WiFi and parking enhance your stay, while the helpful staff ensures comfort just minutes from Central Park.
$111 nightly
The price is $128
Jun 21 - Jun 22
Total with taxes and fees
Drury Inn & Suites Sikeston, MO

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (361 reviews)
Nestled in Mountain View, this welcoming inn offers complimentary breakfast, WiFi, and parking. Active travelers can use the 24-hour fitness center or explore nearby hiking trails. Guests consistently praise the helpful staff and spotless rooms.
$110 nightly
The price is $119
Jun 11 - Jun 12
Total with taxes and fees
Honeysuckle Inn - Mountain View

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (593 reviews)
Close to Perryville Country Club and Saint Marys Lake, this hotel offers free breakfast, WiFi, and parking. Guests love the helpful staff and clean rooms. Take a morning swim or workout at any hour during your business trip or leisure getaway.
$101 nightly
The price is $116
Jun 14 - Jun 15
Total with taxes and fees
Holiday Inn Express & Suites Perryville by IHG

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (84 reviews)
Located in Sikeston, this hotel offers free breakfast, WiFi, and parking. Take a refreshing swim in the indoor pool or grab a bite at the restaurant. Nearby attractions include Central Park and Sikeston Depot Museum for local exploration.
$110 nightly
The price is $125
Jun 18 - Jun 19
Total with taxes and fees
Fairfield Inn & Suites by Marriott Sikeston

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.6 out of 10, Excellent, (559 reviews)
Located in Caruthersville, this hotel offers a casino for entertainment plus peaceful rooms for rest. A short drive from Century Casino and the public library, you'll enjoy free WiFi, parking, and attentive staff service throughout your stay.
$86 nightly
The price is $97
Jun 13 - Jun 14
Total with taxes and fees
The Farmstead Hotel

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (913 reviews)
Situated near Poplar Bluff Station, this hotel offers both convenience and comfort with its 24-hour fitness center and refreshing indoor pool. Explore nearby North Main Street Historic District after enjoying the free breakfast and WiFi.
$101 nightly
The price is $114
Jun 14 - Jun 15
Total with taxes and fees
Fairfield Inn & Suites by Marriott Poplar Bluff

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very Good, (1,000 reviews)
Located in a convenient spot in Festus, this quiet hotel gives you easy access to nearby Jorkerst Memorial Park and Sunset Park. Enjoy free continental breakfast, WiFi, parking, plus a fitness center. Guests praise the helpful staff.
$84 nightly
The price is $96
Jun 15 - Jun 16
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Madison Inn Lodge

Madison Inn Lodge
2.5 star property
Fredericktown
7.6 out of 10, Good, (303 reviews)
Enjoy tranquil surroundings at this well-maintained Fredericktown lodge featuring a seasonal outdoor pool. Complimentary weekend continental breakfast, WiFi, and parking enhance your stay. Located within driving distance of Arcadia Valley Station for regional exploration.
$82 nightly
The price is $90
Jun 11 - Jun 12
Total with taxes and fees
Madison Inn Lodge

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (594 reviews)
Overlooking the Mississippi River, this hotel puts you near Isle Casino Cape Girardeau and Riverfront Park. Enjoy 2 restaurants including Beacon 53, plus free WiFi and complimentary parking during your business-friendly stay.
$122 nightly
The price is $138
Jun 14 - Jun 15
Total with taxes and fees
The Riverview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Check out pet-friendly hotels in Southeast Missouri

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Southeast Missouri

Learn more about Southeast Missouri

Southeast Missouri is well-known for its wineries and riverfront while attractions include K Bridge Recreation Area and Clearwater Lake. This family-friendly city has something for everyone including its university life, restaurants, and sights like Lake Wappapello and Arcadia Valley Golf Club.

Photo by Bill Dillard
Open Photo by Bill Dillard

Check out reviews of Southeast Missouri hotels guests love

Frequently asked questions

Why should I book my Southeast Missouri accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Missouri travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Southeast Missouri

Embrace the River's Whisper: Discover the Blossoming Soul of Southeast Missouri

Southeast Missouri is a hidden gem brimming with natural beauty and cultural charm. Nestled near the vibrant Southeast Missouri State University, this region offers lush landscapes along the Mississippi River, perfect for outdoor adventures like fishing and hiking. Explore the blooming wildflowers in the picturesque parks or indulge in local flavors at quaint eateries. The rich history and welcoming communities provide a unique glimpse into the heart of Americana. Whether you're seeking a romantic getaway or an off-the-beaten-path adventure, Southeast Missouri invites you to discover its captivating allure.

Discover great hotels near Southeast Missouri

Southeast Missouri offers a variety of hotel accommodations, from budget-friendly options to luxury stays, particularly in Cape Girardeau. You'll find deals catering to both leisure and business travelers, with convenient access to attractions and Southeast Missouri State University, ensuring a comfortable stay for all visitors. Here are some of our travelers' favorite hotels near Southeast Missouri:

  1. Madison Inn LodgeOpens in a new window: This budget-friendly motel is ideal for travelers seeking a comfortable and welcoming environment. With a focus on providing a delightful stay, the property offers key amenities that include pet-friendly options, allowing for a unique travel experience. Notable features include a cozy atmosphere perfect for relaxing after a day of exploring. The positive sentiments from travelers highlight the welcoming ambiance and the ease of bringing pets along for the journey, ensuring a memorable trip.
  2. Shepherd Mountain InnOpens in a new window: This charming budget-friendly hotel boasts a remarkable guest rating of 9.2 out of 10, making it a top choice for leisure travelers. With a focus on comfort and tranquility, the hotel offers a peaceful retreat with clean, well-maintained rooms. Guests appreciate the convenient location near beautiful hiking trails, allowing for easy access to outdoor adventures. The inviting atmosphere, friendly staff, and satisfying breakfast create a delightful experience that resonates well with those looking for a quality stay.

Things to do near Southeast Missouri

Southeast Missouri enchants visitors with its lush forests, winding rivers, and blooming wildflowers. Enjoy hiking trails that lead to serene lakes and picnic spots, or explore charming beaches for a day of relaxation. With cozy accommodations nearby, it’s an ideal getaway for nature lovers and outdoor enthusiasts alike.

  • Clearwater LakeOpens in a new window – Dive into the serene beauty of Clearwater Lake, where you can relax by the water, take a leisurely swim, or enjoy a picnic amidst nature. The surrounding landscape is perfect for hiking and birdwatching, offering a peaceful escape for outdoor enthusiasts.
  • Millstream Gardens Conservation AreaOpens in a new window – Discover the lush trails of Millstream Gardens Conservation Area, a reserve that showcases the area’s natural beauty. Stroll along riverside paths adorned with vibrant flowers, and don’t forget to bring your camera to capture the stunning scenery!
  • Lake WappapelloOpens in a new window – Experience the joys of Lake Wappapello, a fantastic spot for fishing, boating, and kayaking. The expansive waters invite you to spend a day on the lake, soaking up the sun and enjoying the gentle breeze.
  • Lake Wappapello State ParkOpens in a new window – Make your way to Lake WappapelloOpens in a new window State Park, where you can hike scenic trails or set up camp under the stars. The park offers ample opportunities for outdoor activities, from biking to wildlife viewing, making it a perfect destination for families.
  • Madison County CourthouseOpens in a new window – Step back in time at the historic Madison County Courthouse. This civic building not only showcases stunning architecture but also allows you to appreciate the rich history of the area. Take a moment to explore the surrounding area and capture some memorable photos.

4 tips for savvy savings when booking a hotel near Southeast Missouri

  1. Book for the cheapest times: The most affordable time to visit Southeast Missouri is during January, November, and December, when hotel prices are typically lower. For a great value for money experience, consider staying for at least 2 to 3 days to fully explore the region's notable landmarks, rich history, and vibrant culture. During your visit, you can enjoy family-friendly activities, dine at cozy cafes, discover local wineries, and take in the beautiful riverside scenery. This budget-friendly getaway offers a chance to connect with friendly locals and appreciate the area's stunning flowers and recreational opportunities, all while keeping your expenses in check.
  2. Look for last-minute deals on Hotels.com: For travelers looking to explore Southeast Missouri, utilizing DealsOpens in a new window and Last-Minute DealsOpens in a new window can be an effective way to discover discounted hotel rates as your travel date approaches. By visiting these sections on Hotels.com, you may find favorable options for accommodations. Additionally, enabling email alerts or push notifications helps you stay informed about time-sensitive promotions. The Smart ShoppingOpens in a new window tool available via the app allows you to compare hotel prices and amenities, ensuring you're more likely to find our best options. This way, you can easily seize opportunities for a last-minute getaway.
  3. Be flexible with dates: Prices can fluctuate based on factors like the hotel's location, star rating, and the time of year, so having some flexibility with your travel dates may help you find a better deal for your stay near Southeast Missouri hotel. If you're interested in a unique experience, boutique hotels often provide a more personalized touch and can sometimes offer better value. When you book through Hotels.com, we’ll inform you if the price for your chosen dates is above or below the average. If it’s on the higher end, we can suggest alternative dates that might be more affordable, helping you explore potential savings.
  4. Consider your location: Staying near key attractions or city centers can be convenient, but it often comes with a higher price tag. If you're looking for more budget-friendly options, consider hotels in less central areas or neighborhoods, which usually tend to be cheaper while still offering reasonable access to the sights you want to see. You might also look into independent hotels a bit further out, as they can offer a more authentic experience at a more affordable rate.

Best time to go to Southeast Missouri

Southeast Missouri has a varied climate due to its size, so the best time to visit depends on the region and your preferences for weather and crowds. June to August are the peak travel months in Southeast Missouri, attracting a higher number of tourists. During this peak period, the weather is mostly sunny, accompanied by light rainfall. On the other hand, January, February, and December tend to be quieter times to visit, marked by light rainfall and mostly sunny conditions.

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