If you're looking to discover somewhere new, look no further than Cayo Santa Maria. Whether you're planning to stay for a night or for the week, the area around Cayo Santa Maria has accommodations to fit every need. Search for hotels in Cayo Santa Maria with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Cayo Santa Maria hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Cayo Santa Maria hotel deals are here with our lowest price guarantee.