Hotels in Defiance, Missouri

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Defiance overview

Make it a point to see sights like Chandler Hill Vineyards and Historic Daniel Boone Home and Heritage Center. Defiance is an inviting destination that has something for everyone.

Where to stay in Defiance

A welcoming city for all, Defiance has a variety of lodging options. There are 141 hotels in the Defiance area and you can shop as many as 17 deals for rooms on Hotels.com, some with discounts of up to 50%.
  • • 54 2-star hotels with an average price of $47 per night
  • • 70 3-star hotels with an average price of $85 per night
  • • 15 4-star hotels with an average price of $89 per night

How to get to Defiance

Fly in to St. Louis, MO (STL-Lambert-St. Louis Intl.), 24.1 mi (38.7 km) from downtown Defiance.

What to see around Defiance

Some highlights of the area include:
  • • Chandler Hill Vineyards
  • • Historic Daniel Boone Home and Heritage Center
  • • Yellow Farmhouse Winery
  • • Broemmelsiek Park
  • • August A. Busch Memorial Conservation Area

When to visit Defiance

If you're still deciding when to visit, here are the seasonal norms to help you plan:

Seasonal temperature averages
  • • January-March: 62°F day, 22°F night
  • • April-June: 88°F day, 39°F night
  • • July-September: 89°F day, 50°F night
  • • October-December: 74°F day, 22°F night
Seasonal rainfall averages
  • • January-March: 7.8 inches
  • • April-June: 13.0 inches
  • • July-September: 10.8 inches
  • • October-December: 10.5 inches