Hotels in Seneca

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Free cancellation

Flexible bookings on most hotels*

Where to stay in Seneca?

Top neighborhoods in Seneca

Find out more about Seneca

Spend time visiting the marina and enjoying its coffee shops in Seneca. Nature lovers can visit Lake Keowee and Lake Hartwell. There's plenty more to see, including sights like Keowee Reservoir.

Frequently asked questions

What accommodations do travelers like in Seneca?
Hampton Inn & Suites Seneca-Clemson Area, Tru by Hilton Seneca Clemson and Lakeside Lodge Clemson are all properties that our guests really like.
Where can I find free parking at my hotel in Seneca?
Park your car for free at these properties: Quality Inn Seneca US-123, Hampton Inn & Suites Seneca-Clemson Area, SC and Best Western Seneca-Clemson. There are 5 choices you may want to check out on our site.
Can I book refundable accommodations in Seneca?
If you want the flexibility to change your travel plans to Seneca, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay with my pet in Seneca?
Your furry friend can stay with you at these pet-friendly hotels: Quality Inn Seneca US-123 and Days Inn by Wyndham Seneca / Clemson Area.
Which Seneca hotels do our guests like for their central location?
Our guests rave about the location of Quality Inn Seneca US-123.
Where can I stay in Seneca if I want a budget-friendly accommodation?
Lakeside Lodge Clemson, Quality Inn Seneca US-123 and Fairfield Inn & Suites Seneca Clemson Univ Area are a few accommodations you might want to consider that’ll save you money.
Where can I stay in Seneca if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 147 vacation homes. You also might want to consider one of 10 apartments or 14 cabins.
Where can I stay if I'm traveling to Seneca with my children?
Parents traveling with children may want to consider Days Inn by Wyndham Seneca / Clemson Area, Tru by Hilton Seneca Clemson and Best Western Seneca-Clemson. You can also check out 6 available options on our site.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August with an average temp of 76°F. January and December are the chilliest months when the average temp is 45°F. The rainiest months are August and March.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, our Price Guarantee makes sure you always get the lowest price, and our Rewards Program lets you earn reward nights and save cash.