Hotels in South Main

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Where to stay in South Main?

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 2.2 mi from South Main
9.0 out of 10, Wonderful, (3,823 reviews)
"Very nice place to stay center of medical center close proximity to great places to visit"
United States
Samantha
$132 nightly
The price is $154
Aug 16 - Aug 17
Total with taxes and fees
Blossom Hotel Houston, Curio Collection by Hilton

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
5.5 mi from South Main
8.4 out of 10, Very Good, (4,274 reviews)
"Room was clean, floor was quiet, staff was courteous & professional and the lobby had a cool vibe. Property conveniently located a couple of blocks from Galleria Mall."
United States
Raymond
$115 nightly
The price is $134
Jul 31 - Aug 1
Total with taxes and fees
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

Kozy Houston North

Kozy Houston North
4.0 star property
24.4 mi from South Main
8.8 out of 10, Excellent, (2,165 reviews)
"Wonderful hotel! Staff was amazing."
United States
Phillip
$49 nightly
The price is $58
Aug 17 - Aug 18
Total with taxes and fees
Kozy Houston North

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 6.8 mi from South Main
8.6 out of 10, Excellent, (4,337 reviews)
"Would stay here again! Super nice staff and really close to Daikin Park!"
United States
Tonya
$85 nightly
The price is $99
Jul 29 - Jul 30
Total with taxes and fees
Club Quarters Hotel Downtown, Houston

Marriott Marquis Houston

Marriott Marquis Houston
4.0 star property
6.7 mi from South Main
9.0 out of 10, Wonderful, (1,159 reviews)
"Great facilites, clean and modern, perfect for exploring downtown houston, service was okay. But i have experienced far better service at the houstonian."
United Kingdom
Scott
$233 nightly
The price is $272
Jul 30 - Jul 31
Total with taxes and fees
Marriott Marquis Houston

Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 1.9 mi from South Main
9.2 out of 10, Wonderful, (2,611 reviews)
"First time staying and visiting Houston whit the family, my daughter's loved it. Great place to stay to visit Houston near several great locations, in-between."
United States
Bernardo
$128 nightly
The price is $149
Jul 31 - Aug 1
Total with taxes and fees
Hyatt Place Houston Medical Center

Hotel Ylem

Hotel Ylem
3.5 star property
1.4 mi from South Main
8.4 out of 10, Very Good, (1,527 reviews)
"It isn't the typical stay, in that it is unique and personal feel to the decor and art. The beds are not hard but a bit easier on the back and shoulders (if you are a side sleeper), really decent rates and they have shuttle services to and from the medical factifies in the Downtown Houston area as a complimentary service that is free of charge to and from you appointments. So we will continue our stays in Houston at the Ylem. "
United States
Deanna
$80 nightly
The price is $93
Jul 24 - Jul 25
Total with taxes and fees
Hotel Ylem

The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria, 5.5 mi from South Main
8.6 out of 10, Excellent, (2,126 reviews)
"Great hotel, great area. Above all, the staff was absolutely amazing."
United States
Lee
$134 nightly
The price is $157
Jul 24 - Jul 25
Total with taxes and fees
The Royal Sonesta Houston Galleria

The Whitehall Houston

The Whitehall Houston
4.0 star property
Houston Central Business District, 6.2 mi from South Main
8.6 out of 10, Excellent, (2,297 reviews)
"Very nice clean friendly hotel to stay at. Outdoor bar/restaurant was also amazing!"
United States
Theresa
$129 nightly
The price is $151
Aug 17 - Aug 18
Total with taxes and fees
The Whitehall Houston

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 2.7 mi from South Main
8.4 out of 10, Very Good, (2,027 reviews)
"This is an excellent hotel, great staff, rooms are excellent and close to local Red line tram and eateries in the Medical Center district"
United Kingdom
Gary
$91 nightly
The price is $107
Aug 16 - Aug 17
Total with taxes and fees
Hilton Houston Plaza/Medical Center

DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
4.1 mi from South Main
8.4 out of 10, Very Good, (1,724 reviews)
"Friendly staff at check in/out, valet was quick and polite, rooms are clean and spacious, HBO included. We were 12 minutes from NRG stadium. "
United States
Michael
$89 nightly
The price is $105
Jul 25 - Jul 26
Total with taxes and fees
DoubleTree by Hilton Hotel Houston - Greenway Plaza

Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
6.4 mi from South Main
9.4 out of 10, Exceptional, (1,802 reviews)
"The hotel is conveniently located in Downtown Houston."
United States
Terence
$173 nightly
The price is $203
Aug 2 - Aug 3
Total with taxes and fees
Hilton Americas-Houston

Home2 Suites by Hilton at the Galleria

Home2 Suites by Hilton at the Galleria
3.0 star property
Greater Uptown, 5 mi from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Galleria is nearby as well as good food options. "
United States
Bryce
$106 nightly
The price is $124
Jul 26 - Jul 27
Total with taxes and fees
Home2 Suites by Hilton at the Galleria

Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
4 mi from South Main
7.8 out of 10, Good, (1,532 reviews)
"Great staff. Clean rooms. Great location"
United States
Robert
$63 nightly
The price is $73
Aug 2 - Aug 3
Total with taxes and fees
Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 1.9 mi from South Main
9.2 out of 10, Wonderful, (1,259 reviews)
"Great location to MD Anderson. "
United States
Karie
$118 nightly
The price is $138
Jul 25 - Jul 26
Total with taxes and fees
Hyatt House Houston Medical Center

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
3.9 mi from South Main
9.2 out of 10, Wonderful, (1,003 reviews)
"Wonderful hotel. Staff is amazing. Daughter had surgery and they went out of their way to help out "
United States
Julian
$251 nightly
The price is $294
Aug 13 - Aug 14
Total with taxes and fees
Hotel Zaza Houston Museum District

Grand Tuscany Hotel

Grand Tuscany Hotel
4.0 star property
12.6 mi from South Main
8.0 out of 10, Very Good, (172 reviews)
"Overall great experience, will definitely be going back!!"
United States
Samuel
$96 nightly
The price is $113
Jul 26 - Jul 27
Total with taxes and fees
Grand Tuscany Hotel

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 2.7 mi from South Main
9.2 out of 10, Wonderful, (1,153 reviews)
"Clean Room,Very friendly staff, and close proximity to site of meeting in Texas Medical Center"
United States
Fuller
$173 nightly
The price is $201
Jul 24 - Jul 25
Total with taxes and fees
The Westin Houston Medical Center/Museum District

Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel
4.0 star property
Houston Central Business District, 6.9 mi from South Main
9.2 out of 10, Wonderful, (1,575 reviews)
"Great location, great hotel and staff. Will stay here again. "
United States
larry
$119 nightly
The price is $139
Aug 1 - Aug 2
Total with taxes and fees
Magnolia Hotel Houston, A Tribute Portfolio Hotel

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
Texas Medical Center, 2.5 mi from South Main
9.4 out of 10, Exceptional, (1,005 reviews)
"The staff was very helpful. The room was quiet (on 17th floor) and comfortable. The restaurant has a large excellent menu, and there is a nice lobby bar. A great place to stay at the Texas Medical Center."
United States
Duncan
$158 nightly
The price is $185
Jul 31 - Aug 1
Total with taxes and fees
InterContinental Houston by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.8
Excellent
1,015 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
886 reviews
View
Premium bedding, pillowtop beds, in-room safe, desk
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.0
Good
1,344 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,000 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,005 reviews
View

When is the best time to visit South Main?

Our prices for hotels in South Main are cheapest in August
Price trends for hotels in South Main
Pricing is based on two traveler single night rates
View properties in July
Currently viewing crowd sizes and weather for July.
Typical weather for Houston
July
High 93°F / low 77°F. Sunny most days.
View properties in July
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July, no crowd data, average high temperature 93 degrees Fahrenheit, average low temperature 77 degrees Fahrenheit. Sunny most days.
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August, no crowd data, average high temperature 94 degrees Fahrenheit, average low temperature 78 degrees Fahrenheit. Sunny most days.
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September, no crowd data, average high temperature 89 degrees Fahrenheit, average low temperature 74 degrees Fahrenheit. Sunny most days.
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October, no crowd data, average high temperature 82 degrees Fahrenheit, average low temperature 65 degrees Fahrenheit. Sunny most days.
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November, no crowd data, average high temperature 71 degrees Fahrenheit, average low temperature 56 degrees Fahrenheit. Sunny most days.
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December, no crowd data, average high temperature 65 degrees Fahrenheit, average low temperature 51 degrees Fahrenheit. Sunny most days.
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January, no crowd data, average high temperature 62 degrees Fahrenheit, average low temperature 47 degrees Fahrenheit. Sunny most days.
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February, no crowd data, average high temperature 65 degrees Fahrenheit, average low temperature 50 degrees Fahrenheit. Cloudy most days.
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March, no crowd data, average high temperature 73 degrees Fahrenheit, average low temperature 56 degrees Fahrenheit. Sunny most days.
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April, no crowd data, average high temperature 78 degrees Fahrenheit, average low temperature 62 degrees Fahrenheit. Sunny most days.
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May, no crowd data, average high temperature 85 degrees Fahrenheit, average low temperature 70 degrees Fahrenheit. Sunny most days.
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June, no crowd data, average high temperature 91 degrees Fahrenheit, average low temperature 76 degrees Fahrenheit. Sunny most days.
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Monthly weather averages (ËšF)

Check out reviews of South Main hotels guests love

Frequently asked questions

Is South Main expensive to stay in?
You can find great hotels from $67 in South Main to suit a range of budgets. To find the best low-cost hotel on Hotels.com that meets your needs, apply your search filters and then sort hotels by "Price: low to high".
How can I find discounted rates and deals for South Main hotels?
Discover great deals on hotels in South Main with Hotels.com. Sign up for free to unlock member only prices and start earning rewards. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on South Main hotels.
Can I receive a refund if I cancel my South Main hotel booking?
The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel your booking. Some South Main hotels require you to cancel more than 24 hours before check-in, so look at your booking beforehand. For extra peace of mind before you book, filter hotels by "Property cancellation options" and select "Fully refundable property".
What are some of the best pet-friendly hotels in South Main?
Traveling with your pet doesn't mean sacrificing a great hotel stay. In South Main, our travelers love:
What are some of the best South Main hotels for couples?
One of the best South Main hotels for couples is Wingate Houston near NRG Park/Medical Center. Wingate Houston near NRG Park/Medical Center is a popular hotel with an outdoor pool. Find more romantic South Main hotels by using the "Traveler experience" filter in your search and selecting "Adults only" or "Romantic".
What are some of the best South Main hotels with a pool?
Book a South Main hotel with a pool for some added relaxation or exercise on your trip. Wyndham Houston near NRG Park/Medical Center is a top-rated hotel with an outdoor pool, and an average guest score of 7 out of 10. This hotel also features a restaurant and a bar/lounge. Wingate Houston near NRG Park/Medical Center is another great hotel that features an outdoor pool, along with a free continental breakfast and wedding services. For more South Main hotels with a pool, use the "Amenities" filter in your search and select "Pool" on Hotels.com.
Is it worth staying in South Main?
You're spoilt for choice with 59 hotels in the area so it's easy to find your perfect somewhere. Basing yourself in South Main makes it easy to explore Houston, including the neighborhoods of The Galleria and Texas Medical Center.
Which station is best for South Main?
The main station in South Main is Fannin South Station. If you're staying at a hotel in South Main, check out the nearest station so that you can get around and explore with ease.
What are some great hotels in South Main with balconies?
There are some top hotels in South Main that offer rooms with a balcony. Check out Wyndham Houston near NRG Park/Medical Center which has a high guest score of 7 out of 10, and balconies in some rooms.
Find out more about South Main

Where History Meets Hustle: Discovering South Main's Sporting Spirit

Discover the vibrant charm of South Main in Houston, Texas, where historic sports venues meet modern urban culture. This dynamic district is home to the renowned NRG Stadium and the lively atmosphere of nearby sports facilities, making it a haven for sports enthusiasts. Stroll through eclectic shops, indulge in culinary delights, and soak in the diverse arts scene. With its unique blend of energy and history, South Main offers an exhilarating experience for travelers seeking both excitement and cultural richness in the heart of Houston. Embrace the spirit of Texas in this captivating neighborhood.

Discover great hotels in South Main

South Main in Houston offers a variety of hotel accommodations, from budget-friendly motels to more upscale options with suites and modern amenities. Many hotels provide comfortable guest rooms, convenient locations, pools, and fitness centers, making it easy for travelers to find a place that suits their needs. Here are some of our travelers' favorite hotels in South Main:

  1. Home Place InnOpens in a new window: This 2.0-star motel offers cozy accommodations with essential amenities including Flatscreen TV, Cable TV, and standard Television options. It provides a comfortable and inviting atmosphere for leisure travelers seeking affordable yet enjoyable lodgings. The hotel’s accessible location makes exploring South Main convenient, ensuring guests can easily immerse themselves in the local culture and attractions.
  2. Motel 6 HoustonOpens in a new window: This 2.0-star motel is perfect for travelers looking for a welcoming environment, featuring pet-friendly policies that allow for a unique stay. The property stands out with its LGBTQIA-friendly atmosphere, making it an ideal choice for those wanting a supportive and inclusive experience. With amenities designed for comfort, visitors can indulge in a relaxed setting while enjoying the vibrant community around South Main.
  3. Studio 6 HoustonOpens in a new window: This 2.0-star motel excels in providing a cozy and inclusive environment, specially catering to LGBTQIA travelers. With its pet-friendly policies, this hotel fosters a welcoming atmosphere that is perfect for leisure seekers. Guests can find comfort in its thoughtfully designed spaces while enjoying easy access to the lively offerings of the South Main area, making it a delightful retreat for those looking to explore the local scene.

Top locations to stay in South Main

Staying near Rice University, University of Houston, and NRG Park offers diverse attractions in South Main, Houston, Texas. Rice University boasts cultural venues and shopping, while University of Houston features vibrant nightlife and parks. NRG Park is perfect for sports and entertainment. For first-time visitors, staying near Rice University provides a blend of academia and local charm.

  1. Near Rice UniversityOpens in a new window: Staying near Rice University puts you close to a vibrant cultural scene and beautiful green spaces. You can explore the Houston Natural Science Museum, perfect for a day of discovery, and the Children's Museum of Houston, great for family fun. For cultural attractions, check out the Main Street Theater in Rice Village and the Hobby Center for the Performing Arts, where you can catch a show. Plus, shopping at The Galleria and Highland Village offers a range of options to satisfy your retail cravings.
  2. Near University of HoustonOpens in a new window: This area is bustling with energy and creativity, making it a fantastic spot to stay. You'll have easy access to attractions like Discovery Green, a lovely park that hosts various events and activities. The nearby George R. Brown Convention Center is a hub for many exhibitions and gatherings. When it comes to cultural experiences, the Hobby Center for the Performing Arts and Bayou Music Center are must-visits. Don't forget to explore the Shops at Houston Center for a bit of shopping, too!
  3. Near NRG ParkOpens in a new window: If you're looking for excitement, staying near NRG Park is a great choice. This area is known for its vibrant events and activities, with venues like NRG Stadium and the Toyota Center hosting concerts and sporting events. Outdoor enthusiasts can enjoy nearby parks, while wellness seekers have access to NRG Park and Daikin Park for a breath of fresh air. With a variety of attractions and events happening regularly, there's always something to enjoy just around the corner.

Things to do near South Main

South Main is a lively hub where sports enthusiasm meets vibrant city life. Explore bustling shopping centers, catch an electrifying concert, or enjoy a night at the theater. With nearby parks and scenic trails, you can easily shift gears from urban excitement to outdoor fun, whether hiking, biking, or simply relaxing in nature.

  • NASA Johnson Space CenterOpens in a new window – Dive into the world of space exploration at NASA Johnson Space Center. This iconic facility offers a glimpse into the past and future of human spaceflight. Explore exhibits that showcase the incredible technology behind space missions and meet the engineers and astronauts who make it all happen. Don't miss the chance to see spacecraft up close and learn about the groundbreaking research conducted here.
  • Space Center HoustonOpens in a new window – Just a stone's throw away, Space Center Houston serves as the official visitor center for NASA Johnson Space CenterOpens in a new window. Here, you can engage with interactive exhibits and enjoy live presentations that highlight the wonders of space travel. Make sure to check out the massive Saturn V rocket and the historic spacecraft that have traveled beyond our planet. It's an exciting, educational experience for visitors of all ages.
  • NRG ParkOpens in a new window – Cap off your trip with a visit to NRG Park, a hub for sports and entertainment. This historic sports stadium is home to thrilling events, including football games and concerts. Stroll around the venue to appreciate its architecture and vibrant atmosphere. Whether you're catching a game or enjoying a concert, NRG Park promises an exhilarating experience right in the heart of Houston.

5 tips for savvy savings when booking a hotel in South Main

  1. Book for the cheapest times: The most budget-friendly time to visit South Main is during January, August, and December, when hotel prices tend to be lower. For an affordable and enriching experience, it's recommended to stay at least 2 to 3 days to fully explore the area's historical landmarks and cultural attractions. You can visit sites like memorials, art galleries, historic civic government buildings, and museums, as well as enjoy urban parks and scenic lakes. This duration allows you to appreciate the rich history and vibrant culture South Main has to offer, all while keeping your trip great value for money.
  2. Look for last-minute deals on Hotels.com: To uncover last-minute deals to South Main, visit the DealsOpens in a new window or Last-Minute DealsOpens in a new window sections on Hotels.com, where you may discover discounted hotel rates as your travel date approaches. Enabling email alerts or push notifications ensures you stay informed about flash sales and special promotions, allowing you to seize opportunities for savings. Additionally, the Smart ShoppingOpens in a new window feature in the app helps you compare hotel prices and amenities, so you're more likely to see the best options available. With these tools, you could be among the first to know about price drops or new room availability for your getaway.
  3. Be flexible with dates: Prices can fluctuate due to factors like the hotel's location, star rating, and the time of year, so being flexible with your travel dates might help you save on your stay at a South Main hotel. If you're in search of something special, boutique hotels often provide a more personalized experience and may offer better value. When you book through Hotels.com, we’ll inform you whether the price for your chosen dates is above or below average. If the price is on the higher end, we’ll suggest alternative dates that could be more affordable, increasing your chances of finding a great deal.
  4. Consider your location: Staying near major attractions or downtown areas can be convenient, but it usually tends to come with a higher price tag. For more budget-friendly options, consider hotels in less central neighborhoods, where you can strike a balance between cost and accessibility to the sites you want to visit. You might also look into independent hotels located a bit further out, as they can offer a more authentic and often more affordable experience.
  5. Become a Member: Join our membership program for free and unlock incredible savings on your next stay in South Main! With access to exclusive member prices on over 100,000 hotels worldwide, you can enjoy significant discounts. As a member, you’ll also have the opportunity to advance through tiers, gaining access to amazing perks such as complimentary room upgrades (when available) and discounts on food and beverages at select VIP Access properties. Don’t miss out on the chance to enhance your travel experience—sign up today and start enjoying the benefits!

Best time to go to South Main

South Main has a varied climate due to its size, so the best time to visit depends on the region and your preferences for weather and crowds. If you’re looking to soak up the lively atmosphere in South Main, April, June, and July are the peak months to visit, bustling with fellow travelers. During this peak period, the weather is mostly sunny, with light rainfall. However, if you prefer a more relaxed experience, October to December are perfect for a quieter getaway, marked by light rainfall and mostly sunny conditions.

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