Skip to main content.

Hotels in De Soto, Illinois

Search & Compare De Soto Hotels

Save more with Secret Prices

Get instant savings with Secret Prices

  • Pay now or later on most rooms
  • Free cancellation on most rooms
  • Price Guarantee

Best hotels in De Soto

What's De Soto Like?

If you're looking for a place to get away, look no further than De Soto. Whether you're planning to stay for a night or for the week, the area around De Soto has accommodations to fit every need. Search for hotels in De Soto with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all De Soto hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best De Soto hotel deals are here with our lowest price guarantee.

How to Get to De Soto

Flights to De Soto

  • • Marion, IL (MWA-Williamson County Regional), 12.7 mi (20.5 km) from central De Soto

Things to See and Do in De Soto

Things to See near De Soto:

  • • Southern Illinois University (7.3 mi/11.8 km from the city center)
  • • Railroaders Memorial (6.2 mi/10 km from the city center)
  • • John A. Logan College (8.6 mi/13.8 km from the city center)
  • • Lake Murphysboro State Park (8.8 mi/14.2 km from the city center)

Things to Do near De Soto:

  • • Hickory Ridge Public Golf Center (4.1 mi/6.6 km from the city center)
  • • General John A. Logan Museum (7.3 mi/11.7 km from the city center)